생명공학 분야 최고의 파트너, 라온바이오(주)
제품 상세정보
Origin: TAAM Orleans (France) - 2012
Strain name: 129S2/SvPasOrlRj
Type: Inbred mouse
Couleur et génotype associé : Agouti mouse with white belly, Aw/Aw - MHC: Haplotype H2b
Breeding: Difficult to rear
This strain was created at Columbia University in 1928 by Dunn from a crossbreed of coloured stock
and chinchilla stock (Tyrc-ch) provided by Castle. In 1948, the strain was brought to the Jackson
Laboratory (129/ReJ). In 1953 Stevens took it on and began by studying the genetic basis of
testicular teratomas in mice from the 129 parental strain. In order to determine the cellular origin of
the teratomas he worked on different crossbreeds of 129 stock. His research work resulted in the
creation of the substrains “Steel” and “Ter”.
The 129S2/SvPasOrl strain is a substrain of Steel, resulting from crossbreeding with the C3H-MgfSl-J,
followed by 12-14 generations of further crossbreeding with 129/Sv stock. This resulted in mice with
agouti pigmentation and white bellies. The steel-J mutation increases the incidence of tertomas by
10%. This strain was brought to Dr J.L. Guenet at the Institut Pasteur in 1970.
The 129 family is made up of 3 sub-families with a significant genetic variation. In order to
differentiate these sub-families, the new nomenclature in 1999, completed their code by adding a
letter for each strain. As such, the parental substrain is now 129P, the Steel substrain, 129S and the
“teratoma” (ter) substrain, 129T.