생명공학 분야 최고의 파트너, 라온바이오(주)
제품 상세정보
Strain name: DBA/1JRj
Type : Inbred mouse
Colour and related genotype: Dilute brown mouse
Breeding: Difficult to rear (poor lactation)
The DBA is the oldest of all inbred strains of mice. Its story begins in 1909 when Dr. CC LITTLE began
inbreeding and selecting for coat color. From 1929 until 1930 crosses were made among substrains,
and several new strains were established including DBA/1 and DBA/2.
DBA/1 and DBA/2 differ at a large number of loci including the MHC (Major Histocompatibility
Complex) H2 Haplotype. This heterozygosity is most likely a result of residual heterozygosity in the
strain when the substrains were separated. DBA/1JRj is widely used as a model for rheumatoid
arthritis. Immunisation with type-II collagen results in severe autoimmune polyarthritis. The rates of
induced arthritis vary depending on chosen protocol but remain inferior to 100%. This collageninduced arthritis leads to the same complications as in humans; there is synovial inflammation,
cartilage and bone erosion. Furthermore, as is the case with humans, the sensitivity is linked to the
expression of molecules belong to the MHC H2 haplotype.
DBA/1Rj mice have a moderate sensitivity to the development of atherosclerotic lesions of the aorta
following an atherogenic diet. Old breeders heart and tongue calcification with age. Females can
develop mammary carcinomas.
Important notice: This strain is homozygous for the Cdh23ahl mutation which leads to age-related
hearing loss. Its expression on a DBA/1 background results in progressive hearing loss with onset
after 10 months of age.