Origin: Zentralinstitut für Versuchstierzucht (Hannover) - 1988 (F200) 

Strain name: CBA/JRj 

Type : Inbred mouse 

Colour and related genotype: Agouti mouse 

Breeding: Difficult to rear 

This CBA and its major substrains are known for their use in numerous research fields such as audition, immunology, gerontology, oncology or pharmacology. It has a few bristles on foot pads and some molars can be frequently be found absent. The CBA is therefore broadly distributed, especially due its high spontaneous disease occurrence and its life-span going from 69 up to 117 weeks depending on the substrain and sex. By crossing a DBA male with a Bagg albino female, Strong created the CBA in 1920. The descendants of this cross were both CBA and C3H. Starting from there, C3H were selected for their high mammary tumor incidence while the CBA were selected for their low tendency to develop a low incidence instead. If the CBA has relatively good breeding performance (except for the N substrain) along with good litter sizes, it is not necessarily easy to breed. Except for the mammary tissue, it has a high gross tumor rate and incidence, and when fed lipids at a high level, CBA tend to have a low propensity to atheroma.